In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery

In vivo evaluation of a nanotechnology-based microshunt for filtering glaucoma surgery

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Abstract To carry out the preclinical and histological evaluation of a novel nanotechnology-based microshunt for drainage glaucoma surgery.Twelve New Zealand White rabbits were implanted with a novel microshunt and followed up for 6 weeks.The new material composite consists of t4450 samsung the silicone polydimethylsiloxane (PDMS) and tetrapodal Zinc Oxide (ZnO-T) nano-/microparticles.The microshunts were inserted ab externo to connect the subconjunctival space with the anterior chamber.Animals were euthanized after 2 and 6 weeks for histological evaluation.

Ocular health and implant position were assessed at postoperative days 1, 3, 7 and twice a week thereafter by slit lamp biomicroscopy.Intraocular pressure (IOP) was measured using rebound tonometry.A good tolerability was observed in both short- and medium-term follow-up.Intraocular pressure was reduced following surgery but increased to preoperative levels after 2 weeks.No clinical or histological signs of inflammatory or toxic reactions were seen; the where to buy powdered food coloring fibrotic encapsulation was barely noticeable after two weeks and very mild after six weeks.

The new material composite PDMS/ZnO-T is well tolerated and the associated foreign body fibrotic reaction quite mild.The new microshunt reduces the IOP for 2 weeks.Further research will elucidate a tube-like shape to improve and prolong outflow performance and longer follow-up to exclude medium-term adverse effects.